Integrative expression system for delivery of antibody fragments by lactobacilli.
نویسندگان
چکیده
A series of expression cassettes which mediate secretion or surface display of antibody fragments was stably integrated in the chromosome of Lactobacillus paracasei. L. paracasei producing surface-anchored variable domain of llama heavy chain (VHH) (ARP1) directed against rotavirus showed efficient binding to rotavirus and protection in the mouse model of rotavirus infection.
منابع مشابه
Expression of Human Immunodeficiency Virus Type 1 Neutralizing Antibody Fragments Using Human Vaginal Lactobacillus
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ورودعنوان ژورنال:
- Applied and environmental microbiology
دوره 77 6 شماره
صفحات -
تاریخ انتشار 2011